RESUMO
Analgesic abuse is common in Thailand. Heavy use of analgesic may also increase risk of chronic nephropathy. However, the extent of this risk remains unclear. We carried out a case-control study in three referral hospitals. A total of 84 patients with newly diagnosed of chronic tubulointerstitial nephritis were enrolled as cases. Two control groups were randomly selected, 192 from hospitalized patients who had no renal disease and serum creatinine below 1.2 mg/dl and 166 from relatives of friends visiting the hospitals. Both cases and controls were interviewed by a standardized pre-coded questionnaire to obtain histories of analgesic use before diagnosis of renal disease. On multiple logistic regression analysis, patients whose estimated lifetime use of acetaminophen of 1,000 g or more had an increased risk of chronic nephropathy compared with non-users, the odds ratio (OR) was 5.9 (95% confidence interval (CI) 1.3-25.6, hospital controls) and OR = 5.8 (95% CI 1.04-31.9, visitor controls). Also, uses of aspirin showed a similar relationship. Patients who used aspirin 1,000 g or more per lifetime had higher risk of chronic nephropathy when compared to non-users, the odds ratio were 7.1 (95% CI 2.0-25.8, hospital controls) and 20.4 (95% CI 2.4-174.2) for visitor controls. These data indicate that analgesic abuse increased risk of chronic nephropathy in Thailand.
Assuntos
Acetaminofen , Adulto , Analgésicos não Narcóticos , Anti-Inflamatórios não Esteroides , Aspirina , Estudos de Casos e Controles , Doença Crônica , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Nefrite Intersticial/induzido quimicamente , Razão de Chances , Inquéritos e Questionários , Fatores de Risco , Transtornos Relacionados ao Uso de Substâncias/complicações , TailândiaAssuntos
Adulto , Feminino , Humanos , Injúria Renal Aguda/etiologia , Masculino , Síndrome Nefrótica/complicaçõesRESUMO
The prevalence of hepatitis B virus infection in chronic hemodialysis patients in Bangkok was surveyed. There were 14.7% (10 out of 68 patients) HBAg carriers; 26.5% (18 out of 68 patients) positive for HBAb. Total exposure rate of HBV (28 out of 68 patients) was 41.2% at the beginning of dialysis. The exposure rate converted to be 50% (34 out of 68 patients) at the time of survey. Five cases with abnormal liver function expired while being on the hemodialysis. Acute viral hepatitis was thought to be the cause. One case of possible non A- non B viral hepatitis was discussed.
Assuntos
Adulto , Idoso , Feminino , Hepatite B/sangue , Anticorpos Anti-Hepatite B/análise , Antígenos da Hepatite B/análise , Humanos , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Diálise Renal/efeitos adversos , Tailândia , Fatores de TempoAssuntos
Adulto , Glicina/urina , Humanos , Masculino , Osteomalacia/sangue , Fosfatos/sangue , SíndromeRESUMO
A patient with cerebral malaria complicated by full-blown DIC, after failing to respond to other forms of treatment, was successfully treated by exchange transfusion. To the best of the authors' knowledge, this may be first reported case of full-blown DIC in malaria successfully treated by exchange transfusion.